Determination of Osteocalcin, Bone Alkaline Phosphatase, and Lysyl Oxidase in Iraqi Acromegalic Patients

Main Article Content

Eiman A. Abass Baydaa Ahmed Abed Sohaib N. Mohsin

Abstract

    This study was aimed to determine bone formation markers (OST and BALP) and lysyl oxidase in diabetes and non-diabetes Iraqi acromegaly patients in addition to find the relationship among these parameters. The present study conducted 60 acromegalic patients (30 diabetes & 30 non diabetes) attending National Diabetes Center / AL-Mustansiriya University/Baghdad, and 30 healthy individuals as a control group aged (35-60) years. All patients were administrated Sandostatin drug, and they were diagnosed by physician in the hospital.FBG, GH, IGF-1, OST, BALP, and LOX were determined in all groups. The results showed a highly significant rise in all parameters (GH, IGF-1, FBG, OST, BALP, and LOX values in serum of all patients when compared with normal individuals. There were a positive highly significant correlations for lysyl oxidase with osteocalcin and a positive significant with BALP in acromegalic patients. We concluded that lysyl oxidase may be a novel   biomarkers in endocrine diseases like acromegaly.

Article Details

How to Cite
ABASS, Eiman A.; ABED, Baydaa Ahmed; MOHSIN, Sohaib N.. Determination of Osteocalcin, Bone Alkaline Phosphatase, and Lysyl Oxidase in Iraqi Acromegalic Patients. Ibn AL- Haitham Journal For Pure and Applied Science, [S.l.], v. 31, n. 1, p. 172-179, may 2018. ISSN 2521-3407. Available at: <http://jihcoed.com/ihj/index.php/j/article/view/1864>. Date accessed: 15 oct. 2018. doi: http://dx.doi.org/10.30526/31.1.1864.
Section
Chemistry