Spectrophotometric Determination of Sulfamethoxazole Based on Charge-Transfer Complexation with Sodium Nitroprusside

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Tariq Y. Mahmoud Sarmad B. Dikran Alaa K. Mohammed

Abstract

   A simple, accurate and precise spectrophotometric method has been developed for the analysis of sulfamethoxazole (SMZ) in pure form and pharmaceutical preparation. The method involves a direct charge transfer complexation of sulfamethoxazole (SMZ) with sodium nitroprusside (SNP) in alkaline medium and the presence of hydroxyl amine hydrochloride. Variables affecting the formation of the formed orange colored complex were optimized following two approaches univariate and central composite experimental design (CCD) multivariate. Under optimum recommended conditions, the formed complex exhibits λmax at 512 nm and the method conforms Beer's law for SMZ concentration in the range of 5.0-150.0 (µg.mL-1) with molar absorptivity 1.139×103 L.mol-1.cm-1, and r = 0.9997. Analysis of SMZ pharmaceutical dosages shows a good agreement with the real amounts.

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How to Cite
MAHMOUD, Tariq Y.; DIKRAN, Sarmad B.; MOHAMMED, Alaa K.. Spectrophotometric Determination of Sulfamethoxazole Based on Charge-Transfer Complexation with Sodium Nitroprusside. Ibn AL- Haitham Journal For Pure and Applied Science, [S.l.], v. 30, n. 3, p. 102-113, dec. 2017. ISSN 2521-3407. Available at: <http://jihcoed.com/ihj/index.php/j/article/view/1606>. Date accessed: 16 aug. 2018. doi: http://dx.doi.org/10.30526/30.3.1606.
Section
Chemistry